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Proto Sheetmetal Manufacturing ProtoCAM is the clear selection for additive manufacturing and fast prototyping. Advanced additive manufacturing and fast industrial 3D prototyping providers for defense, aerospace, automotive, medical, architecture, shopper items and more. Our mixture of trusted professionals, superior expertise, high-availability infrastructure and compassionate, seamless, and customized companies is setting the trade standard for around-the-clock access to help carried out right. Proco Products are leading verify valve manufacturers and suppliers designing price efficient check valves to forestall the again move of fluids and gases. "Greek Structure Sunbeam" Here is a remake of a song the band did again within the Nineteen Seventies. Whatever edginess the original had has been rubbed away right here; this rendition is even mellower. Most verbs are both "robust" or "weak" in conjugation; there are seven lessons of robust verbs and three classes of weak verbs. Proto Final The bonus display screen is a somewhat bland green display similar to that in Doki Doki Panic. The last uses the prototype's title display screen palette with a black background, which itself obtained reused because the Super Mario USA title screen. The slots additionally use the unique item graphics as a substitute of edited ones. Proto Final The Character Select screen has an ellipsis between "EXTRA LIFE" and the quantity of lives, which was faraway from the ultimate however added back in Super Mario All-Stars. Browse other questions tagged javascript prototype javascript-objects prototypal-inheritance or ask your individual question. The black arrow has no particular that means, other than the property of the item. Cat.__proto__ points to the Function.prototype object, just like Function.__proto__ and Object.__proto__ do. Tom.__proto__ property points to the same object as Cat.prototype. One factor to maintain an eye fixed out for is the group's tendency to present their suggestions and insights to the moderator as opposed to their teammates. The team should debate one another, not you, so ensure the conversation is being redirected as needed. Once full, the executives current their personas to the group by studying each out loud and sticking it up on a wall. The team then provides suggestions on which qualities of each persona are practical or unrealistic, and on-the-spot adjustments are made. With a Windows XP, 7,eight or 10 Control Interface the TAIGTURN 2000DSLS system can produce prime quality parts in prototype or industrial production environments. Quickly consider as many makes and fashions of cars that you can in 30 seconds. Each a kind of autos has hundreds of custom components specific to that make, mannequin and yr. If the participant chooses to not struggle towards Wood Man or loses to him, Proto Man will rescue Mega Man and says he has to battle with all his power against Wily's robots. After the fight towards Crash Man, Mega Man reaches an space monitored by a number of robots, having the selection to proceed now as there is no time to lose, or wait to get darkish to move unnoticed. If the participant select to continue, Proto Man seems and says Mega Man ought to be cautious and wait for it to get darkish before running to the again of the temple.

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Designed by Steve Grabowski from actual drawings of the prototype's manufacturer, Standard Steel of Pennsylvania, then transformed to CAD drawings by Carl Jackson, the Protocraft wheel is an actual mannequin of the prototype. Produced on Brown & Sharpe lathes from gentle steel , the manufacturing of the wheel is a two-part difficult course of, requiring a second collet operation to machine the again facet profile. This is a labor intensive course of and is the one wheel available on the market with full again side and correct hub detail. The axle, also produced from prototype drawings, is machined on a Swiss Screw Machine. Each axle follows the proper hub and contour based on it is tonnage rating, hence every axle put in within the respective ton-rated wheel matches the tonnage score for the wheelset. TURNING TO CRIME is an oldies but goodies type of album taking you back to the years of good quaint rock and roll. While at first look i assumed this album was going to be terrible but once i lowered my expectation sufficient i was immediately shocked that this album isn't that dangerous at all! While the band's songwriting has deteriorated over time, the musicians' capacity to carry out has not.

• Cells will start to develop out of control, which results in cancer.
• Aerospace was one of many first industries to undertake 3D printing.
• Proto-personas are a variant of the everyday persona, with the essential distinction that they do not appear to be initially the outcome of person analysis.
• Ideally, all product design actions are then refocused on the present theories of who the customers truly are.
• If the participant choose to proceed, Proto Man appears and says Mega Man ought to be cautious and anticipate it to get dark before running to the back of the temple.
• Moving a number of optionally available fields right into a newoneof may be secure if you are sure that no code units greater than separately.

For instance, one spectrum could be a customer-specific attribute such as years of experience along with your product or within your industry. Another good example of a persona spectrum is tech savviness. Find attributes that not solely enable the company to differentiate between different personas however which are also related to your services and products. On the primary day, convey the staff of executives collectively for a three hour session, beginning with a short introductory presentation. The presentation ought to convey that the purpose of the proto-persona workshop is to have a look at the corporate from the customer's perspective and to articulate who the purchasers are and what wants they have that affect the company. Introduce the executive staff to the concept of an ad-hoc persona as a illustration of the archetypal "people" they consider will be their clients now and sooner or later. ISO C does not permit this instance, because subword arguments in old-style non-prototype definitions are promoted. Therefore on this example the perform definition's argument is really an int, which doesn't match the prototype argument kind of brief. As standard enterprise apply we frequently review our provide chain dependencies and this coverage will continue to make sure that we maintain our service levels. With this design aid for injection moulding you will study the fundamentals for the manufacturing of high-quality plastic parts. Henderson, NV 89012Email This email address is being protected against spambots. All memberships embody limitless free access to our proprietary PROTOGYM private training software. Utilizing the most recent in exercise science, PROTOGYM lets you obtain any fitness goal. Our unqiue software program uses your physique, equipment, and health level to create a truly custom-made health answer. C-erb, c-fos, c-jun, c-myb, c-myc, c-mos, c-raf, c-ras; POs act in regular development, differentiation, and induction and/or maintenance of CA. So, Constructor operate Foo has a prototype property which factors to its prototype, which is Foo.prototype . // prototype was created routinely once we declared the operate Foo. It ought to've really been referred to as something like, "prototypeToInstall", since that is what it is. The month-to-month returns are then compounded to reach on the annual return. Only Zacks Rank stocks included in Zacks hypothetical portfolios firstly of every month are included in the return calculations. Zacks Ranks stocks can, and infrequently do, change all through the month. At first glance, one will discover the sharp edges and little to no offset that makes these irons strikingly completely different from anything played on Tour. Proto-Cutter has become a trusted name in gap ending tools due to our high quality requirements, unmatched customer support, and fast lead instances, that are qualities we additionally apply to our special made-to-print objects. We are dedicated to providing high quality instruments at affordable costs and look forward to serving all of your cutting device wants. Grind, round, deburr, clean, and polish complex and excessive precision metallic elements easier than ever before with the DLyte Compact Series from GPAINNOVA. We pride ourselves on our excessive normal of high quality and, fairly frankly, cannot think about doing anything. With the Studio System they saved vital costs, time, and weight with the ultimate elements. ProtoCAM just lately labored with a buyer on a medical speedy prototyping project involving knee alternative orthopedic prototype. Fused Deposition Modeling is a 3D rapid prototype approach that makes use of engineering-grade thermoplastics such as ABS and polycarbonate. FDM is good for take a look at prototypes uncovered to chemical, temperature or mechanical stress. The solely downside I even have noticed was it rode a bit completely different on the flats then my different 2 boards, just took some getting use to. Definitely a worthy board and the other 2 at the second are in semi-retirement for sure. A single nucleotide change, which alters codon 12 from GGC to GTC , is answerable for the transforming activity of the rasH oncogene detected in bladder carcinoma DNA. RSV accommodates a further gene, src, that's not current in ALV and encodes the Src protein-tyrosine kinase. The X80 Proto is the first automotive in the sequence to be based on a concept hyper/racing automobile, particularly the Ferrari F80 Concept, as seen within the frontal styling, particularly within the grille area, facet profiling and intakes. It also a bears sturdy resemblance to the Devel Sixteen. In addition to such alterations in gene expression, oncogenes incessantly encode proteins that differ in structure and performance from these encoded by their normal homologs. Many oncogenes, corresponding to raf, are expressed as fusion proteins with viral sequences on the amino terminus (Figure 15.21). Such deletions might outcome within the loss of regulatory domains that control the activity of the proto-oncogene proteins, thereby producing oncogene proteins that operate in an unregulated method. For example, the viral raf oncogene encodes a fusion protein in which amino-terminal sequences of the traditional Raf protein have been deleted. These amino-terminal sequences are important to the conventional regulation of Raf protein kinase exercise, and their deletion ends in unregulated constitutive exercise of the oncogene-encoded Raf protein. After debugging any issues make certain to take away the save calls. While this code is easy it can be difficult to understand what's taking place inside features and loops. A lot of developers reach for logging or printing to debug this kind of code. When you try this across a quantity of functions and namespaces those values are combined collectively and separate from the code. Download this guide to discover the processes involved in creating sheet steel parts together with tips on how to design widespread features and choose the proper materials. Get a practical snapshot of the surface finishes that are possible on machined plastic and steel parts. This guide contains high-quality photographs of your surface finish choices at Protolabs. On the front finish, the car is clearly distinguished by its sharp end on the centre, adopted by giant frontal intakes on both sides, with carbon-fibre sections on the lower parts. The headlights are extraordinarily sharply shaped and enormous, and progress from the interior of the upper frontal intakes to down the edges of the front fenders. The bonnet space contains a triangular strip on the centre that's completed in carbon fibre, bearing the Grotti emblem on the front. Through the front windscreen, two adjustable shock absorbers and comes for the frontal suspension could be seen. The horizontal alignment of these suspension parts implies the utilization of a pushrod-actuated front suspension setup. This board simply changed my ability stage up a pair notches, I've been driving the proto 2 and did I suppose that board was awesome, until I received on the FR 161x. The FR could be very stable at excessive speeds and the control of the triple camber edges holds far better then I was expecting. I wasn't sure the way it was going to deal with the groomers, it blew me away at the way it grabs corners. How ever didn't get a lot of powder runs on my final trip last month the temps were beneath 0, so the snow was crunchy. I'm an older boarder at fifty eight and dial it back somewhat more those days. Python is a little completely different — the Python compiler generates a module with a static descriptor of every message kind in your .proto, which is then used with a metaclass to create the mandatory Python knowledge entry class at runtime. As you'll have the ability to see, each field within the message definition has a novel quantity. These area numbers are used to identify your fields within the message binary format, and should not be modified once your message kind is in use. However, since he was created too unbiased, Proto Man feared the modification would change his character. Proto Man refused to have Dr. Light meddle together with his techniques and fled to guard his sense of id. VPN Accelerator is a set of technologies unique to ProtonVPN that may enhance your VPN speeds by over 400%. We imagine privateness and security are elementary human rights, so we additionally present a free version of ProtonVPN to the public. Every instance created utilizing new Person() has a __proto__ property which points to the Person.prototype. This is the chain that is used to traverse to find a property of a selected object. This README file contains protobuf set up instructions. To set up protobuf, you want to set up the protocol compiler (used to compile .proto files) and the protobuf runtime on your chosen programming language. Originally, proto3 messages always discarded unknown fields throughout parsing, but in model 3.5 we reintroduced the preservation of unknown fields to match the proto2 habits. Dr. Proto makes a speciality of all elements of the foot and ankle and is board certified in forefoot and rearfoot reconstructive surgical procedure. Benjamin R. Proto, DPM, FACFAS, joined TPMG Orthopedics in 2007, and has established himself as one of the Peninsula's main foot and ankle specialists, providing his patients the latest advancements in foot and ankle care. Purchase consists of SOUND FILES ONLY. No physical saber or product shall be shipped or provided. A decide sentenced Jussie Smollett to a hundred and fifty days in jail, branding the Black and homosexual actor a narcissistic charlatan for staging a hate crime against himself to grab the limelight whereas the nation struggled with... Grippers are fast, clean and have unmatched traction on all terrains and are undeniably the most effective. The Proto FR is superb, it digs trenches, is very secure at excessive velocity and on variable snow. It is nimble and agile, responding immediately to any move the rider makes. This board is so much fun and so reliable, Never Summer out did themselves with this board. Hence myobject.prototype wouldnt be a property of the actual object as a outcome of its just a short-term factor used by the constructor perform to outline what myobject.__proto__ ought to look like. Over forty several sorts of proto-oncogenes have been found in the human physique. When a mutation happens in a proto-oncogene, it turns into completely activated. The gene then starts making too much of the proteins that code for cell development. Unknown fields are well-formed protocol buffer serialized data representing fields that the parser doesn't acknowledge. The remaining 1,891 ORFs (1,139 ORFs 0+ and 752 ORFs1-4) present traits intermediate between non-genic ORFs and genes, assembly our proto-gene designation (Fig. 4a, Supplementary Fig. 8 and Supplementary Table 3). We suggest to put these ORFs in a continuum where strict annotation boundaries no longer have to be set (Fig. 4b). To take a look at the evolutionary continuum prediction, we first verified that ORF conservation degree correlates positively with length and expression level (Fig. 2a and Supplementary Fig. 5)1,10-12. These correlations counsel that genes evolve from non-genic ORFs that lengthen and increase in expression degree over evolutionary time. A negative correlation between ORF length and expression level21 was noticed amongst ORFs5-10, however not amongst ORFs1-4 (Supplementary Fig. 5).

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However, as all of the oldest types of the languages are represented within the information, the ancient languages still absent in PIE Lexicon are supplemented within the close to future. Proto-Indo-European Lexicon is the generative etymological dictionary of Indo-European languages. "Utopian Dream" Fortunately, Proto-Kaw ends on a really high note, with fine acoustic guitars and occasional discharges of electrical lead. Some options are message-level options, that means they should be written inside message definitions. Some options are field-level choices, that means they should be written inside field definitions. Options may also be written on enum varieties, enum values, oneof fields, service varieties, and repair strategies; however, no useful choices presently exist for any of these. People provide you with sensible new ideas and enhancements to current merchandise and most don't know tips on how to make these ideas a actuality. Designs corporations are the next step; they take ideas and put them on paper and create CAD files. We work with design firms to make their digital models into physical prototypes. You are utilizing a model of browser that received't display all the features of this website. Proto-Elamite is the final un-deciphered writing system from the Ancient Near East with a substantial number of sources . It was used for a relatively brief interval round 3000 BC throughout what is today Iran. Proto-Elamite is a derived writing system originating from the Uruk invention of writing in southern Mesopotamia in the course of the middle of the 4th millennium BC. Scribes in Susa in southwestern Iran took over a majority of the numerical indicators as well as most of the numerical systems from the older proto-cuneiform system. Currently the runtime libraries for working with Any varieties are under development. Following a difficult January where its manufacturing line was badly affected by unresolved flooding issues, national automobile maker PROTON rebounded in February with a 107% improve in gross sales. The company offered 9,225 items (domestic + export) final month, permitting it to reclaim second place in the automotive gross sales table and putting it on observe to recuperate lost sales from January. From order to supply, our knowledgeable, on-site customer service staff is all the time obtainable to help with no matter you need. We also have space sales representatives who present regional help across the us and past. Get quality machined components fast and with cost-efficient pricing to meet all of your project needs. "Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the creating lamellipodia." "VE-cadherin signaling induces EB3 phosphorylation to suppress microtubule development and assemble adherens junctions." "Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling." "Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling advanced formation." "Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions." The XCB project has a protracted history, throughout which it has produced many educational publications.

Beginning A Self Hosted Clojurescript Repl

It is also essential to stress that these will be ad-hoc personas and not scientifically proven buyer archetypes. Nevertheless, the proto-personas might be reference points that the team can use as lenses via which customer-centric views can be seen in ongoing planning and decision-making processes. This article explains tips on how to construct and refine proto-personas. The proto-personas might be refined and improved via user analysis later so they can be used with extra confidence by product teams, however their roots within the boardroom additionally wins the arrogance of administration. Once proto-personas are created and agreed upon, it is imperative that researchers then take them into the field to start validating their accuracy. As holes are poked into the unique persona hypotheses, they are revamped and rewritten. However, it can be transformed into an ONCOGENE by, for instance, MUTATION. The PROTO Gripper was the world's first freestyle scooter wheel and the primary product officially launched underneath the PROTO brand in 2008. The success of the PROTO Gripper has earned it the popularity as the head of excessive efficiency freestyle scooter wheels and was the springboard for every little thing that followed. The original Full Core launch was adopted shortly after with our iconic 5-Spoke PROTO Logo core which are unmistakable whenever you see them. The downstream targets of PI 3-kinase/Akt signaling embody a member of the Bcl-2 household , and it's notable that Bcl-2 was first discovered as an oncogene in human lymphomas. The bcl-2 oncogene is generated by a chromosome translocation that ends in elevated expression of Bcl-2, which blocks apoptosis and maintains cell survival under situations that usually induce cell demise. Translocations of different proto-oncogenes incessantly lead to rearrangements of coding sequences, resulting in the formation of abnormal gene merchandise. The prototype is translocation of the abl proto-oncogene from chromosome 9 to chromosome 22 in persistent myelogenous leukemia (Figure 15.25). This translocation leads to fusion of abl with its translocation companion, a gene called bcr, on chromosome 22. This reconstructed father or mother language is typically called merely Indo-European, however in this article the term Proto-Indo-European is most well-liked. We've created a new place the place questions are at the center of learning. Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians. Finally, stick every consumer on the wall with their descriptions. As a group, focus on every of the customers and their unique circumstances. This property is of no use till you utilize this perform as constructor perform i.e. with the 'new' keyword. To retrieve the worth of obj.__proto__ is like calling, obj.__proto__() which truly returns the calling of the getter fn, Object.getPrototypeOf which exists on Object.prototype object. Although .__proto__ is a settable property but we must always not change [] of an already current object because of efficiency issues. When we create a perform a, prototype is automatically created as a special property on a and saves the perform code on as the constructor on prototype. Then, when this perform is utilized as a constructor function, the thing instantiated from it'll obtain a property referred to as __proto__. These services permit Proto Cast to provide the stamping business with the best quality instruments delivered on time. In a race to build tomorrow, the smallest particulars can have the greatest impression on design integrity, product high quality, and velocity to market. Since 1986, Sierra Circuits has developed a status for excellence in PCB prototype manufacturing, optimization, and meeting. Choose one of the methods given under to put in protoc. We thrive on the demands and deadlines that are inherent with the automotive sector and production of present automobiles for the world stage. Explore our capabilities and tasks both previous and present, and then contact us utilizing the net form below to arrange an onsite go to or for an preliminary casual discussion about your requirements. Colocalizes with RGS14 and BRAF in each the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the lively Ras protein. Music which once more makes a pleasing smile on my face on a daily basis. Joyful, relaxing, dramatic on locations however not taking the issues very critically, melodic and memorable. There are again woodwinds and wonderful flutes throughout, as properly as Livgren's excellent guitar licks, which did not lose any power with the time. With dynamic referencing you'll be able to take the system anyplace and have correct and repeatable 3D scanning ends in any surroundings. It is the right software for reverse engineering and inspection throughout the whole product development lifecycle. As the first binder jetting system designed for machine outlets, Shop SystemTM lets your shop benefit from inexpensive, high-quality binder jetting know-how. We present our prospects with end-to-end options from idea to prototype, through design iterations, to low and mid-volume production. The majority of oncogene proteins operate as elements of the signaling pathways that regulate cell proliferation and survival in response to growth factor stimulation. These oncogene proteins embrace polypeptide development elements, growth issue receptors, elements of intracellular signaling pathways, and transcription components (Figure 15.26). A distinct mechanism by which oncogenes are activated in human tumors is gene amplification, which ends up in elevated gene expression. Indeed, novel oncogenes have been identified by molecular cloning and characterization of DNA sequences that are amplified in tumors.

Retroviral Oncogenes

Livgren then teamed up with Steve Walsh, Phil Ehart, Rich Williams, Robbie Steinhardt and Dave Hope to type KANSAS which grew to become the KANSAS we all know (and love!). PROTO-KAW members are Livgren, Lynn Meredith on vocals, Dan Wright on organ, John Bolton on sax and flute, Craig Kew on bass and Brad Schulz on bass. The liner notes pay tribute to former member Don Montre who handed away at age 39. Overall, our outcomes present that de novo gene start might proceed by way of proto-genes. From the initial complete set of candidate proto-genes (all ORFs0 and ORFs1-4), we excluded ORFs0 that appear to lack translation signatures according to our stringent pipeline (Supplementary Fig. 6). The 25 ORFs4 which would possibly be longer than 300 nucleotides, present signatures of translation and are underneath purifying selection, can confidently be thought-about genes despite being weakly conserved. Cerevisiae doubtless holds for different species and should lengthen to RNA genes and regulatory parts. Examination of translation program remodelling upon stress, in light of our evolutionary mannequin, may additional understanding of phenotypic range and plasticity of cellular systems7,28. Make your prototypes look actual by including interactions to your designs. ProtoPie fills a niche in the market by creating essentially the most powerful prototypes with out code. Instead, KING CRIMSON released their debut somewhat later and have been topped the forefathers of prog, when in actuality, TOUCH did it first. This album is a strong 5 STARS for me, I really have heard it a number of instances now and each time it has grown increasingly dear to me. At first, I was delay by this album because it was onerous to search out, the sound-quality was fairly unhealthy and the cover appeared really odd in my opinion. Since the Plomb tool models have been nicely documented, we'll think about a number of the newer or different Proto instruments right here. A 1961 P&C catalog reveals adjustable wrenches with a ridge across the hanging gap. In 1948 adjustable wrenches marked with each Proto and Plomb (PRVTV-PLVMB) have been made with a plain hanging hole , as a substitute of the broached hole beforehand provided. Penens catalogs from 1951 and 1955 illustrate adjustable wrenches with a plain hanging hole. The early history of the Plomb Tool Company leading up to the creation of the Proto model has been lined in our article onPlomb Tool. In this text we'll concentrate on events from 1950 onward referring to the event of the Proto model and the affiliated firms. We work with our prospects and provide them with a wide selection of options to satisfy their quality and aesthetics all whereas staying within their required timeframe. Invite a vast variety of people to view your prototype, present comments on Cloud, and create shareable links. PROTOGYM offers a variety of semi-private group health lessons. The combine of sophistication types is designed to offer each client probably the most comprehensive training program obtainable. The semi-private environment offers the personal attention wanted for results without having to pay the premium value for one-on-one training. Also, all courses at PROTOGYM are blind to capacity degree, so consultants may be grouped with novices. In addition, Proto hand instruments are made within the USA to make sure the highest quality and most durability in the business Every Proto tool has gone through rigorous testing to ensure it won't fail on the job. Plus, they're ergonomically designed with handles that offer you a firm grip and special options that prevent slippage. Our clients vary from Fortune one hundred companies, to startups and colleges - all using our on-line design platform to ideate fast, collaborate and optimise prototypes earlier than development. Active and keen college students from Creative Technology and Interaction Technology come collectively in Study Association Proto. One thing Proto stands out for is its various, however close group. Students with completely different nationalities, experiences, interests and skills type the premise on which this neighborhood is constructed. The manufacturing date might be sometime in the Fifties. The inset reveals the forged-in code "B.8.7" on the reverse. The inset reveals the forged-in code "PJ.three.2" on the reverse. By the mid Sixties the Penens Corporation had modified its name to the Fleet Tool Company. This change probably occurred in 1964 or 1965, but we haven't found documentation for the precise date. The firm continued to supply tools beneath the Fleet brand, but presumably with out the Penens marking. Note that the groups function is deprecated and shouldn't be used when creating new message sorts. By default, you ought to use definitions solely from immediately imported .proto recordsdata. However, sometimes you could want to maneuver a .proto file to a new location. Forth continues in a similar type to the earlier two albums but perhaps one may say that this one is somewhat bit slicker compared to Before Became After and The Wait Of Glory. While some songs are every bit as progressive and almost nearly as good as the fabric on these previous albums, there are right here also a couple of more straightforward, bluesy rockers that I don't care all that much for. Certainly a newcomer ought to best start with Before Became After and The Wait Of Glory, however anyone who admires those albums will most likely find something to like here as nicely. Wu DD, Irwin DM, Zhang YP. De novo origin of human protein-coding genes. A, Characterization of candidate proto-genes (ORFs 0+ and ORFs1-4). This article is excerpted from An Austrian Perspective on the History of Economic Thought, vol. An MP3 audio file of this text, read by Jeff Riggenbach, is out there for download. Not that John Law neglected the low-interest argument for Dutch prosperity.